From KernelEx Wiki
KernelEx offers the possibility to choose between different compatibility modes to install and run apps.
1. Use default compatibility options (KernelEx is enabled)
2. disable KernelEx extensions
Disable KernelEx, if an app, which don't need it, has some glitches or shows any problems.
3. Use specfic compatibility mode:
There are Default mode; Win 95; Win 98SE; Win ME; Win NT4.0 SP6; Win 2000 SP4; Win XP SP2; Win 2003 SP1; Win Vista; Win 2008 SP1; disable custom heap
The Advanced options aren't available with "Use default compatibility options (KernelEx is enabled)" mode.